Are Diabetic Drugs Causing Cancer? New Research

Could your medication be causing cancer? Unfortunately, it’s true. In this study there was only a single medication for diabetes that didn’t increase cancer risk.

First of all, let me point out just how incredibly dangerous the diabetic AND prediabetic states are for human physiology. There is arguable nothing more damaging to our health, even cigarette smoking. Yes–more dangerous than smoking. Of course, a smoker who is prediabetic or diabetic will have a very high risk of most chronic diseases.

The diabetic state is one that we constantly fight against. In reality, it is our protection against starvation and hardship. Sound strange? It is, looking at today’s society, where calories are in abundance and there is no metabolic cost to get them (compare walking to the fridge vs hunting a boar for days…). With the exception of the past 100 years or so, starvation was the norm. Our bodies are extremely well developed at surviving adversity, so we do well with this scenario.

This also smashes the “bad genes” concept. Those most prone to diabetes actually have the toughest genes–genes designed to store calories for a rainy day. But that rainy day never comes in today’s society because lots and lots of poor quality calories are found everywhere.

So back to this particular article. Based on increasingly strong links between diabetes and many types of cancer, the researchers looked at how much diabetic medications may be contributing.

Certainly, diabetes itself and the elevated insulin that accompanies it will increase the risk of cancer. Insulin is a proliferative hormone and causes cells to divide more. More cell division increases the risk of an error. An error may lead to cancer. You get the picture.

Diabetic medications, with the exception of metformin, doubled the risk of being diagnosed with cancer. If one of these diabetics that got cancer was on insulin, their risk of dying was 400% greater.

For anyone that thinks that diabetic drugs are lifesavers needs to read this article. The ONLY thing that is a lifesaver is to make the appropriate anti-diabetic lifestyle changes such as..

Merely chewing more times before swallowing has consistently shown to improve the way our bodies respond to the food we it, steering our physiology away from diabetes and towards health.

Eat more nuts. Make sure there are NO added oils–just raw nuts or roasted and salted with no added oils like cottonseed or peanut oil. These will undo the benefits of the nuts.

Avoid artificial sweeteners like the plague. Despite the common use and recommendation of artificial sweeteners like aspartame and sucralose, study after study confirms that these compounds actually promote diabetes, likely by disconnecting our taste from our response to calories.

Try supplements. Many supplements have been shown to help diabetes such as magnesium, fish oils and folic acid. These can be powerful aids to your dietary changes.

Calorie restriction. Cutting back on our calories while increasing the quality of those calories (i.e. your 1200 calories per day comes from broccoli and not from a value meal) is the single most powerful change that can impact diabetes. Study have shown that diabetics on insulin can be off their insulin in one week with controlled calorie restriction.

The list is actually quite endless and each change compliments the other. But it is not a single change, but rather changes in diet, chemical exposure, stress levels and exercise that all come together as a powerful tool to steer us away from diabetes.

For more information http://www.sciencedirect.com/science/article/pii/S0026049510003367

However, for those of you thinking that maybe metformin doesn’t look to bad after reading this study needs to look at the cost comparison between lifestyle changes ($1100) and metformin ($31,300). Again, lifestyle wins hands down. http://www.annals.org/content/142/5/323.abstract

Diabetes Type 2 Management – Anti-Diabetic Drugs (Sulfonylureas and Biguanides)

The prevalence of diabetes type 2 has reached epidemic proportions worldwide and it is projected to still increase dramatically. Diabetes type 2 is caused by insulin resistance (decreased responsiveness to insulin) in the body cells mainly in the liver, skeletal muscle and adipose tissue, or it can also be caused by a reduced level of insulin secretion by the pancreas, or a mixture of both.

Moreover, the prevalence of insulin resistance (poor response of body cells to insulin) which is a major causative factor in the early development of type 2 diabetes is even more widespread.

Although dietary modification and increased physical activity provide some level of control, this is often insufficient and most diabetics will still require some form of drug treatment.

Presently there are 5 different types of oral anti diabetic drugs used for treating type 2 diabetes;

a – Sulfonyureas
b – Meglitinides
c – Biguanides
d – Thiazolidinediones
e – Alpha – glucosidase inhibitors

Sulfonylureas

These drugs are derived from sulfunic acid urea. They have been the cornerstone of type 2 diabetes treatment since the 1950’s

– They have proven efficacy in most patients.
– Low incidence of side effects.
– They act by directly stimulating insulin production in pancreatic B cells.
– Major side effects include hypoglycemia (over reduced and low blood sugar levels} and weight gain.
– Dosage is started from low doses.
– Examples include 1st generation drugs like chlorpropamide (diabenese}, tolbutamide, and acetohexamide.

2nd generation drugs like glyburide, glypizide and glimepiride

Biguanides

This drug is a synthetic analogue of guanidine

– This drug has surpassed sulfonylureas as the most prescribed oral antidiabetic drug in the US and in the European markets it is the second most prescribed antidiabetic drug after glyburide.

– It is recommended as the 1st line of treatment in newly diagnosed diabetics.
– It acts by suppressing basal hepatic glucose production (glucose production in the liver).
– It also improves whole body insulin stimulated glucose metabolism (it makes the body cells more responsive to insulin).
– It also has reduces the levels of triglycerides (fat} and free fatty acids in the body.
– Side effects include gastrointestinal disturbances like diarrhea, abdominal pain, it also causes lactic acidosis occasionally.
– It should not be taken by people with poor kidney function, and in people with liver disease.
– The most common example is metformin.

News About the Type 2 Diabetes Drug Avandia

Studies continue to try to dive into the cause and cure for type 2 diabetes and the drug once thought to be a major breakthrough for type 2 diabetes, Avandia, is coming under a lot of significant study and skepticism.

Health Canada is currently claiming that the deaths of six Canadians are “very likely” linked to the Type 2 Diabetes drug Avandia, which of course raises concerns about whether the potential detrimental effects of the drug are worth the risks. Other studies on the drug Avandia indicate that it may be linked to a much higher risk of heart attack in certain patients, according to reports in the respected New England Journal of Medicine. To support this study, Health Canada says that 28 Canadians who had been taking Avandia for type 2 diabetes had suffered heart attacks since being introduced to the drug Avandia in 2000. In the US, there have been 19 confirmed reports of heart attacks from US citizens who have been taking Avandia.

While this is not a lot of people based on the number of total people taking Avandia, the number is statistically significant, and people taking a drug for one ailment should not be “e encouraging” another, potentially life-threatening disorder. More clinical study is needed, but the evidence exists that there is probably a connection between the heart attacks and Avandia. While the studies do not conclusively prove that Avandia is the culprit and Avandia has definitely been ruled out in some of the heart attack cases, there are strong signs that it is a factor in the majority of the cases.

A review published in the New England Journal of Medicine indicates multiple studies on the drug Avandia which indicate a higher risk of heart attack in approximately 43% of patients who take the drug.

The pharmaceutical firm GlaxoSmithKline PLC manufactures Avandia. To add to their problems, the Food and Drug Administration has declined to grant a priority review to their newest experimental cancer vaccine Cervarix, which serves to add pressure to the company with the current controversy surrounding their manufacture of Avandia. The Avandia family of drugs manufactured by Glaxo includes Avandamet and Avandaryl, which showed sales last year of well over a billion dollars. This makes the Avandia family of drugs the second best selling drug after the company’s Advair product which is for asthma treatment.

While Glaxo claims that the reported incidents of heart attack are “statistically the same” for Avandia patients as those patients who are on other anti-diabetes drugs, it remains clear that further research and study is required before these drugs can be claimed safe and effective for treating what they were designed to treat.